Absolutely. There are many Auto Profit situations that you can take advantage of. It's not luck in the long run. Holdem is firmly based on mathematics.
One simple example. If you bet $10 into a $10 pot then you have 1:1 pot odds. If your opponent folds more than 50% of the time you will make an Automatic Profit. See my post on MDF and GTO.
With practice you can easily learn what automatic profit strategies look like and how easy they are to use against opponents that do not have well thought out strategies of their own. Minimum Defense Frequencies, C-Bet and Barreling are a few.
There are also many specific exploits. All of your opponents make mistakes, even the professionals. At the lower levels, mistakes are the rule, not the exception.
If your opponent is a good player, they are more likely to fold to a Raise than a poor player. A Fish often refuses to fold anything on the flop.
PeakHoldem can dramatically improve your win rate. Every future release of PeakHoldem will increase the accuracy of opponent play. Unique enough to be patent pending. 62/732,519.